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We offer technical expertise and scientific support for product development and applications based on synthetic cells and organelles ​

Unlock the Future of Cellular Assays with Our Synthetic Cell Models

Dive into the world of precision with our patented synthetic cell designs. Crafted from a diverse range of materials like giant unilamellar vesicles, colloidosomes, polymerosomes, droplet emulsions, hydrogels, and coacervates, our models are revolutionizing cellular and molecular assays.

Why Choose Our Synthetic Cells?

  • Precision Mimicry: Our synthetic cells emulate the vital attributes of natural cells and organelles, from membrane properties to mechanical characteristics.
  • Customizable Design: Being synthetic, they can be finely tuned to mirror the specific traits of their natural counterparts.
  • Industry-Ready: Trusted by industry partners for flow cytometry analysis, immune cell activation, and probing molecular interactions.
 
Relevant publications:
  1. Staufer O.*, Dietrich F., Rimal R., Schröter M., Fabritz S., Böhm H., Singh S., Möller M., Platzman I., Spatz JP.* (2021) Bottom-up assembly of biomedical relevant fully synthetic extracellular. Science Advances 7 (36), eabg6666
  2. Staufer O.*, Schröter M., Platzman I., Spatz JP.* (2020) Bottom-up assembly of functional intracellular synthetic organelles by droplet-based microfluidics. Small e1906424
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Fully synthetic extracellular veiscles and viruses

The scientific community is increasingly turning its attention to subcellular structures. Among these, extracellular vesicles (EVs) like exosomes have garnered significant interest for their potential as therapeutic and diagnostic tools. Yet, the inherent heterogeneity of these structures, coupled with the challenges in their production, purification, and engineering, can be daunting.

Our solution? A patented, high-throughput droplet-based assembly technology. This innovation allows us to create fully synthetic liposome analogs that not only mirror the vesicular structure of EVs but also emulate their functions, including therapeutic capabilities. These synthetic structures offer enhanced controllability and precision at the molecular level, and they’re already making waves as internal standards and controls in EV assays.

Drawing parallels between EVs and viruses, some theories suggest a shared evolutionary origin. Building on this connection, we’ve extended our technology to craft synthetic virions. These virions, with their defined molecular properties, are proving invaluable as standards for functional assays, be it neutralization tests or avenues in drug delivery.

 

Relevant publications:

  1. Staufer O.*, Gupta K., Hernandez J., Kohler F., Sigl C., Singh G., Vasileiou K., Macher M., Fabritz S., Dietz H., Cavalcanti-Adam EA., Schaffitzel C., Ruggieri A., Platzman I., Berger I. Spatz JP.* (2021) Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein. Nature Communications 13, 868
  2. Staufer O.*, Dietrich F., Rimal R., Schröter M., Fabritz S., Böhm H., Singh S., Möller M., Platzman I., Spatz JP.* (2021) Bottom-up assembly of biomedical relevant fully synthetic extracellular. Science Advances 7 (36), eabg6666
  3. Staufer O.*, Hernandez Bücher J., Fichtler J., Schröter M., Platzman I., Spatz JP. (2022) Vesicle induced receptor sequestration: mechanisms behind extracellular vesicle-based protein signaling. Advanced Science 9(13), 2200201
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